Input interpretation
tyrosine degradation I (human metabolic pathway)
Alternate name
tyrosine fumarate catabolism
Pathway topology
Pathway topology
Pathway components
| L-tyrosine | (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | 3-(4-hydroxyphenyl)-L-alanine | L-(-)-tyrosine | p-tyrosine | (S)-2-amino-3-(4-hydroxyphenyl)propionic acid | 181.2 g/mol | | (HO)C_6H_4CH_2CH(NH_2)CO_2H | 4-hydroxyphenylpyruvic acid | 3-(4-hydroxyphenyl)-2-keto-propionic acid | 3-(4-hydroxyphenyl)-2-oxo-propanoic acid | 3-(4-hydroxyphenyl)-2-oxopropanoic acid | 3-(4-hydroxyphenyl)pyruvic acid | benzenepropanoic acid, 4-hydroxy-alpha-oxo- | p-hydroxyphenylpyruvic acid | test acid e | 180.2 g/mol | | HOC_6H_4CH_2COCO_2H | homogentisate | 2, 5-dihydroxyphenylacetate | 168.1 g/mol | | C_8H_8O_4 | 4-maleyl-acetoacetate | 200.1 g/mol | | C_8H_8O_6 | 4-fumaryl-acetoacetate | 200.1 g/mol | | C_8H_8O_6 | acetoacetic acid | 102.1 g/mol | | C_4H_6O_3 | fumaric acid | allomaleic acid | boletic acid | but-2-enedioic acid | trans-1, 2-ethylenedicarboxylic acid | trans-butenedioic acid | 116.1 g/mol | | HOOCCH=CHCOOH
Pathway steps
| reaction ⟶ | + 2-ketoglutarate ⟶ + L-glutamate | tyrosine aminotransferase ⟶ | + oxygen ⟶ + CO_2 | 4-hydroxyphenylpyruvate dioxygenase ⟶ | + oxygen ⟶ | homogentisate 1, 2-dioxygenase ⟶ | ⟶ | maleylacetoacetate isomerase ⟶ + | + H_2O ⟶ + | fumarylacetoacetase
Related pathways
| overlapping components TCA cycle | TCA cycle variation III (eukaryotic) | pyruvate fermentation to propionate I | mixed acid fermentation | glutamate degradation VII | lysine fermentation to acetate and butyrate |