Input interpretation
arginine degradation VI (arginase 2 pathway) (human metabolic pathway)
Alternate name
proline biosynthesis from arginine
Pathway topology
Pathway topology
Pathway components
| L-arginine | (S)-2-amino-5-guanidinopentanoic acid | 174.2 g/mol | | H_2NC(=NH)NH(CH_2)_3CH(NH_2)CO_2H | L-ornithine | 132.2 g/mol | | C_5H_12N_2O_2 | L-glutamate gamma-semialdehyde | glutamic gamma-semialdehyde | L-glutamate-5-semialdehyde | glutamate-semialdehyde | 131.1 g/mol | | C_5H_9N_1O_3 | (S)-1-pyrroline-5-carboxylate | pyrroline 5-carboxylate | L-Delta1-pyrroline-5-carboxylate | (S)-1-pyrroline-5-carboxylate | 1-pyrroline-5-carboxylate | L-1-pyrroline-5-carboxylate | delta-1-pyrroline-5-carboxylic acid | delta-1-pyrroline-5-carboxylate | 113.1 g/mol | | C_5H_7N_1O_2 | L-proline | (2S)-pyrrolidine-2-carboxylic acid | (S)-pyrrolidine-2-carboxylic acid | 115.1 g/mol | | C_5H_9NO_2
Pathway steps
| reaction ⟶ | + H_2O ⟶ + urea | arginase II, mitochondrial precursor | arginase 1 ⟶ | + 2-ketoglutarate ⟶ + L-glutamate | ornithine aminotransferase, mitochondrial precursor ⟶ | ⟶ + H_2O | (none) ⟶ | + NAD(P)H + H+ ⟶ + NAD(P)+ | pyrroline 5-carboxylate reductase isoform | pyrroline-5-carboxylate reductase | pyrroline 5 carboxylate reductase
Related pathways
| overlapping components proline biosynthesis V (from arginine) | citrulline biosynthesis | arginine degradation I (arginase pathway) | proline biosynthesis II | urea cycle | citrulline-nitric oxide cycle |