Input interpretation
proline biosynthesis II (human metabolic pathway)
Alternate name
prosyn
Pathway topology
Pathway topology
Pathway components
| 2-oxoglutaric acid | 2-ketoglutaric acid | 2-oxo-1, 5-pentanedioic acid | 2-oxopentanedioic acid | alpha-ketoglutaric acid | 146.1 g/mol | | C_5H_6O_5 | D-glutamic acid | (2R)-2-aminopentanedioic acid | D-glutamate | 147.1 g/mol | | C_5H_9NO_4 | L-glutamate-5-phosphate | L-gamma-glutamyl-5-phosphate | L-gamma-glutamyl-5-P | L-glutamyl-5-phosphate | 227.1 g/mol | | C_5H_10N_1O_7P_1 | L-glutamate gamma-semialdehyde | glutamic gamma-semialdehyde | L-glutamate-5-semialdehyde | glutamate-semialdehyde | 131.1 g/mol | | C_5H_9N_1O_3 | (S)-1-pyrroline-5-carboxylate | pyrroline 5-carboxylate | L-Delta1-pyrroline-5-carboxylate | (S)-1-pyrroline-5-carboxylate | 1-pyrroline-5-carboxylate | L-1-pyrroline-5-carboxylate | delta-1-pyrroline-5-carboxylic acid | delta-1-pyrroline-5-carboxylate | 113.1 g/mol | | C_5H_7N_1O_2 | L-proline | (2S)-pyrrolidine-2-carboxylic acid | (S)-pyrrolidine-2-carboxylic acid | 115.1 g/mol | | C_5H_9NO_2
Pathway steps
| reaction ⟶ | + ammonia + NAD(P)H ⟶ + NAD(P)+ + H_2O | glutamate dehydrogenase 2 | glutamate dehydrogenase 1, mitochondrial precursor ⟶ | + ATP ⟶ + ADP | glutamate 5-kinase ⟶ | + NADPH + H+ ⟶ + NADP+ + phosphate | gamma-glutamyl phosphate reductase ⟶ | ⟶ + H_2O | (none) ⟶ | + NAD(P)H + H+ ⟶ + NAD(P)+ | pyrroline 5-carboxylate reductase isoform | pyrroline-5-carboxylate reductase | pyrroline 5 carboxylate reductase
Related pathways
| overlapping components citrulline biosynthesis | proline biosynthesis V (from arginine) | arginine degradation VI (arginase 2 pathway) | arginine degradation I (arginase pathway) | glutamate degradation VII | histidine degradation III |