Input interpretation
4-hydroxyproline degradation I (human metabolic pathway)
Alternate name
4-hydroxyproline degradation
Pathway topology
Pathway topology
Pathway components
| hydroxyproline | (2S, 4R)-4-hydroxyproline | (2S, 4R)-4-hydroxypyrrolidine-2-carboxylic acid | 4-hydroxy-L-proline | hydroxy-L-proline | Hyp | L-hydroxyproline | trans-hydroxyproline | 131.1 g/mol | | C_5H_9NO_3 | pyrroline-hydroxy-carboxylate | L-Delta1-pyrroline 3-hydroxy-5-carboxylate | 129.1 g/mol | | C_5H_7N_1O_3 | L-erythro-4-hydroxy-glutamate | 4-Hydroxy-L-glutamate | erythro-4-hydroxyglutamate | 4-Hydroxy-L-glutamic acid | 163.1 g/mol | | C_5H_9N_1O_5 | D-4-hydroxy-2-keto-glutarate | 4-hydroxy-2-oxoglutarate | D-4-hydroxy-2-ketoglutarate | 2-k-4-OH-glutarate | 2-keto-4-hydroxyglutarate | 2-Oxo-4-hydroxyglutarate | 4-hydroxy-2-ketoglutarate | 162.1 g/mol | | C_5H_6O_6 | pyruvic acid | α-ketopropionic acid | 88.1 g/mol | | CH_3COCOOH | glyoxylic acid | formylformic acid | glyoxalic acid | oxalaldehydic acid | oxaldehydic acid | oxoacetic acid | oxoethanoic acid | 74 g/mol | | OHCCOOH
Pathway steps
| reaction ⟶ | + oxygen ⟶ + H_2O | (none) ⟶ | + NAD+ + H_2O ⟶ + NADH | delta-1-pyrroline 5 carboxylate dehydrogenase mitochondrial precursor | aldehyde dehydrogenase 4A1 precursor ⟶ | + 2-ketoglutarate ⟶ + L-glutamate | (none) ⟶ + | ⟶ + | (none)
Related pathways
| overlapping components glyoxylate cycle | glycolysis V | glycolysis I | mixed acid fermentation | lactate oxidation | Entner-Doudoroff pathway II (non-phosphorylative) |