Input interpretation
arginine degradation I (arginase pathway) (human metabolic pathway)
Alternate names
glutamate biosynthesis | arginase degradative pathway
Pathway topology
Pathway topology
Pathway components
| L-arginine | (S)-2-amino-5-guanidinopentanoic acid | 174.2 g/mol | | H_2NC(=NH)NH(CH_2)_3CH(NH_2)CO_2H | L-ornithine | 132.2 g/mol | | C_5H_12N_2O_2 | L-glutamate gamma-semialdehyde | glutamic gamma-semialdehyde | L-glutamate-5-semialdehyde | glutamate-semialdehyde | 131.1 g/mol | | C_5H_9N_1O_3 | (S)-1-pyrroline-5-carboxylate | pyrroline 5-carboxylate | L-Delta1-pyrroline-5-carboxylate | (S)-1-pyrroline-5-carboxylate | 1-pyrroline-5-carboxylate | L-1-pyrroline-5-carboxylate | delta-1-pyrroline-5-carboxylic acid | delta-1-pyrroline-5-carboxylate | 113.1 g/mol | | C_5H_7N_1O_2 | D-glutamic acid | (2R)-2-aminopentanedioic acid | D-glutamate | 147.1 g/mol | | C_5H_9NO_4
Pathway steps
| reaction ⟶ | + H_2O ⟶ + urea | arginase II, mitochondrial precursor | arginase 1 ⟶ + | + 2-ketoglutarate ⟶ + | ornithine aminotransferase, mitochondrial precursor ⟶ | ⟶ + H_2O | (none) ⟶ | + NAD+ + H_2O ⟶ + NADH | delta-1-pyrroline 5 carboxylate dehydrogenase mitochondrial precursor | aldehyde dehydrogenase 4A1 precursor
Related pathways
| overlapping components citrulline biosynthesis | proline biosynthesis V (from arginine) | arginine degradation VI (arginase 2 pathway) | proline biosynthesis II | urea cycle | histidine degradation III |