Input interpretation
citrulline-nitric oxide cycle (human metabolic pathway)
Alternate name
citrulline-NO cycle
Pathway topology
Pathway topology
Pathway components
| L-arginino-succinate | N-(L-arginino)-succinate | arginino-succinate | 290.3 g/mol | | C_10H_18N_4O_6 | L-arginine | (S)-2-amino-5-guanidinopentanoic acid | 174.2 g/mol | | H_2NC(=NH)NH(CH_2)_3CH(NH_2)CO_2H | L-citrulline | 175.2 g/mol | | C_6H_13N_3O_3
Pathway steps
| reaction ⟶ | ⟶ + fumarate | argininosuccinate lyase ⟶ | + NADPH + oxygen ⟶ + NADP+ + nitric oxide | ENOS interacting protein | nostrin | nitric oxide synthase, inducible | nitric-oxide synthase IIC (fragment) | nitric-oxide synthase IIB | nitric-oxide synthase, brain | nitric-oxide synthase, endothelial ⟶ | + ATP + L-aspartate ⟶ + AMP + diphosphate | argininosuccinate synthase
Related pathways
| overlapping components urea cycle | proline biosynthesis V (from arginine) | citrulline biosynthesis | arginine degradation VI (arginase 2 pathway) | arginine degradation I (arginase pathway) |