Input interpretation
![heme biosynthesis from uroporphyrinogen I (human metabolic pathway)](../image_source/d385ba3935c6082994d3b26484b23f7a.png)
heme biosynthesis from uroporphyrinogen I (human metabolic pathway)
Pathway topology
![Pathway topology](../image_source/9376e0540f39804775735cf069c8e5e3.png)
Pathway topology
Pathway components
![| uroporphyrinogen-III | 836.8 g/mol | | C_40H_40N_4O_16 | coproporphyrinogen III | coproporphyrinogen | 660.8 g/mol | | C_36H_40N_4O_8 | protoporphyrinogen IX | protoporphyrinogen | 568.7 g/mol | | C_34H_36N_4O_4 | protoporphyrin IX | 566.7 g/mol | | C_34H_33N_4O_4 | heme | 616.5 g/mol | | C_34H_32FeN_4O_4](../image_source/bbc83b2efa14f51af5bebb8c952613d7.png)
| uroporphyrinogen-III | 836.8 g/mol | | C_40H_40N_4O_16 | coproporphyrinogen III | coproporphyrinogen | 660.8 g/mol | | C_36H_40N_4O_8 | protoporphyrinogen IX | protoporphyrinogen | 568.7 g/mol | | C_34H_36N_4O_4 | protoporphyrin IX | 566.7 g/mol | | C_34H_33N_4O_4 | heme | 616.5 g/mol | | C_34H_32FeN_4O_4
Pathway steps
![| reaction ⟶ | ⟶ + CO_2 | uroporphyrinogen decarboxylase ⟶ | + oxygen + H+ ⟶ + CO_2 + H_2O | coproporphyrinogen III oxidase, mitochondrial precursor ⟶ | + oxygen ⟶ + H_2 | protoporphyrinogen oxidase ⟶ | + Fe_2+ ⟶ + H+ | ferrochelatase, mitochondrial precursor](../image_source/6004333e000dc703035151017e233a9c.png)
| reaction ⟶ | ⟶ + CO_2 | uroporphyrinogen decarboxylase ⟶ | + oxygen + H+ ⟶ + CO_2 + H_2O | coproporphyrinogen III oxidase, mitochondrial precursor ⟶ | + oxygen ⟶ + H_2 | protoporphyrinogen oxidase ⟶ | + Fe_2+ ⟶ + H+ | ferrochelatase, mitochondrial precursor
Related pathways
![| overlapping components tetrapyrrole biosynthesis II | tetrapyrrole biosynthesis I |](../image_source/2f5aaaad24689c2bb1626e0a88b0ad44.png)
| overlapping components tetrapyrrole biosynthesis II | tetrapyrrole biosynthesis I |