Input interpretation
heme biosynthesis from uroporphyrinogen I (human metabolic pathway)
Pathway topology
Pathway topology
Pathway components
| uroporphyrinogen-III | 836.8 g/mol | | C_40H_40N_4O_16 | coproporphyrinogen III | coproporphyrinogen | 660.8 g/mol | | C_36H_40N_4O_8 | protoporphyrinogen IX | protoporphyrinogen | 568.7 g/mol | | C_34H_36N_4O_4 | protoporphyrin IX | 566.7 g/mol | | C_34H_33N_4O_4 | heme | 616.5 g/mol | | C_34H_32FeN_4O_4
Pathway steps
| reaction ⟶ | ⟶ + CO_2 | uroporphyrinogen decarboxylase ⟶ | + oxygen + H+ ⟶ + CO_2 + H_2O | coproporphyrinogen III oxidase, mitochondrial precursor ⟶ | + oxygen ⟶ + H_2 | protoporphyrinogen oxidase ⟶ | + Fe_2+ ⟶ + H+ | ferrochelatase, mitochondrial precursor
Related pathways
| overlapping components tetrapyrrole biosynthesis II | tetrapyrrole biosynthesis I |