Input interpretation
leucine biosynthesis (human metabolic pathway)
Pathway topology
Pathway topology
Pathway components
| sodium 3-methyl-2-oxobutanoate | 3-methyl-2-oxobutanoic acid sodium salt | 3-methyl-2-oxobutyric acid sodium salt | alpha-ketoisovalerate | butanoic acid, 3-methyl-2-oxo-, sodium salt | ketovaline sodium salt | sodium 2-keto-3-methyl-butyrate | sodium 3-methyl-2-oxo-butanoate | sodium dimethylpyruvate | α-ketoisovaleric acid sodium salt | 138.1 g/mol | | (CH_3)_2CHCOCOONa | 2-isopropylmalate | 3-hydroxy-4-methyl-3-carboxypentanoate | 3-carboxy-3-hydroxy-4-methylpentanoate | 3-carboxy-3-hydroxy-isocaproate | alpha-isopropylmalate | (2S)-2-isopropylmalate | 176.2 g/mol | | C_7H_12O_5 | isopropylmaleate | 2-Isopropylmaleate | beta-isopropylmaleate | 2-isopropylmaleic acid | 158.2 g/mol | | C_7H_10O_4 | 3-isopropylmalate | 2-D-threo-hydroxy-3-carboxy-isocaproate | 3-carboxy-2-hydroxy-4-methylpentanoate | beta-isopropylmalate | (2S)-3-isopropylmalate | 176.2 g/mol | | C_7H_12O_5 | 2-isopropyl-3-oxosuccinate | (2S)-2-isopropyl-3-oxosuccinate | 174.2 g/mol | | C_7H_10O_5 | 2-ketoisocaproate | 2-keto-4-methyl-pentanoate | 2-oxoisocaproate | 4-methyl-2-oxopentanoate | 2-oxo-4-methylpentanoate | alpha-ketoisocaproate | alpha-oxoisocaproate | 130.1 g/mol | | C_6H_10O_3 | L-leucine | (2S)-2-amino-4-methyl-pentanoic acid | pentanoic acid, 2-amino-4-methyl-, (S)- | 131.2 g/mol | | (CH_3)_2CHCH_2CH(NH_2)CO_2H
Pathway steps
| reaction ⟶ | + acetyl-CoA + H_2O ⟶ + coenzyme A | (none) ⟶ | ⟶ + H_2O | (none) ⟶ | + H_2O ⟶ | (none) ⟶ | + NAD+ ⟶ + NADH + H+ | (none) ⟶ | ⟶ + CO_2 | (none) ⟶ | + L-glutamate ⟶ + 2-ketoglutarate | branched-chain amino acid aminotransferase, mitochondrial precursor | branched-chain amino acid aminotransferase, cytosolic
Related pathways
| overlapping components valine biosynthesis |