Input interpretation
TCA cycle (human metabolic pathway)
Alternate names
TCA | citric acid cycle | tricarboxylic acid cycle | TCA cycle - aerobic respiration
Pathway topology
Pathway topology
Pathway components
| citric acid | 2-hydroxy-1, 2, 3-propanetricarboxylic acid | 2-hydroxypropane-1, 2, 3-tricarboxylic acid | aciletten | anhydrous citric acid | citretten | citric acid, anhydrous | citro | 192.1 g/mol | | HOC(COOH)(CH_2COOH)_2 | cis-aconitic acid | 1-propene-1, 2, 3-tricarboxylic acid, cis- | 1-propene-1, 2, 3-tricarboxylic acid, (Z)- | cis-1-propene-1, 2, 3-tricarboxylic acid | (Z)-1-propene-1, 2, 3-tricarboxylic acid | (Z)-aconitic acid | 174.1 g/mol | | C_6H_6O_6 | D-isocitrate | isocitric acid | isocitrate | threo-Ds-isocitrate | I-CIT | 192.1 g/mol | | C_6H_8O_7 | 2-oxoglutaric acid | 2-ketoglutaric acid | 2-oxo-1, 5-pentanedioic acid | 2-oxopentanedioic acid | alpha-ketoglutaric acid | 146.1 g/mol | | C_5H_6O_5 | succinyl-coenzyme a | 867.6 g/mol | | C_25H_40N_7O_19P_3S | succinic acid | 118.1 g/mol | | HOOCCH_2CH_2COOH | fumaric acid | allomaleic acid | boletic acid | but-2-enedioic acid | trans-1, 2-ethylenedicarboxylic acid | trans-butenedioic acid | 116.1 g/mol | | HOOCCH=CHCOOH | (S)-malic acid | (2S)-2-hydroxybutanedioic acid | (2S)-2-hydroxysuccinic acid | (-)-hydroxysuccinic acid | L-hydroxybutanedioic acid | L-malic acid | (S)-(-)-2-hydroxysuccinic acid | 134.1 g/mol | | HO_2CCH_2CH(OH)CO_2H | oxalacetic acid | 2-oxobutanedioic acid | ketosuccinic acid | oxaloacetic acid | oxosuccinic acid | 132.1 g/mol | | HOCOCOCH_2COOH | acetyl-CoA | acetyl coenzyme-A | ac-CoA | acetylcoenzyme-A | acetyl-S-CoA | ac-S-CoA | 809.6 g/mol | | C_23H_38N_7O_17P_3S_1
Pathway steps
| reaction ⟶ | ⟶ + H_2O | aconitase 1 | aconitate hydratase, mitochondrial precursor ⟶ | + H_2O ⟶ | (none) ⟶ | + NADP+ ⟶ + CO_2 + NADPH | NADP+-specific isocitrate dehydrogenase (fragment) | isocitrate dehydrogenase 2 (NADP+), mitochondrial precursor | isocitrate dehydrogenase (NADP) cytoplasmic ⟶ | + coenzyme A + NAD+ ⟶ + CO_2 + NADH | 2-oxoglutarate dehydrogenase E1 component | 2-oxoglutarate dehydrogenase ⟶ | + ADP + phosphate ⟶ + ATP + coenzyme A | succinyl-CoA ligase (ADP-forming) beta-chain, mitochondrial precursor ⟶ | + a ubiquinone ⟶ + a ubiquinol | succinate dehydrogenase (ubiquinone) flavoprotein subunit mitochondrial precursor ⟶ | + H_2O ⟶ | fumarate hydratase, mitochondrial precursor ⟶ | + NAD+ ⟶ + NADH | malate dehydrogenase, mitochondrial precursor | malate dehydrogenase cytoplasmic | malate dehydrogenase, cytoplasmic
Related pathways
| overlapping components TCA cycle variation III (eukaryotic) | glutamate degradation VII | mixed acid fermentation | pyruvate fermentation to propionate I | glyoxylate cycle | degradation of pyrimidine deoxyribonucleosides |